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After injecting the serum, a younger version of Elisabeth, named Sue (Margaret Qualley), physically bursts out of her back. The One Rule:

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The film follows Elisabeth Sparkle (Demi Moore), a fading Hollywood star and fitness instructor who is fired from her show on her 50th birthday for being "too old". Desperate to reclaim her youth, she turns to a black-market drug called The Substance After injecting the serum